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False-col TEM of fibrils in mad cow disease
Bovine spongiform encephalopathy (BSE). False- colour transmission electron micrograph of fibrils, coloured blue, in an extract of fresh brain from a cow infected with BSE, a form of transmissible, slow virus encephalopathy. Human slow virus encephalopathies include Kuru, Creutzfeldt-Jakob disease, & Gerstmann-Straussler syndrome. The agents causing these diseases form a group of virus-like organisms called prions. The fibrils are believed to be aggregations of the major proteins of the infectious agents themselves. Magnification: x67,500 at 6x4.5cm size, x36,300 at 35mm size.
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