Tophus due to gout. Artwork of the bones of a foot, showing a tophus (swelling) due to gout. At upper left, the tophus is seen at the base of the big toe. The area is red and inflamed. Gout is a disease in which a defect in uric acid metabolism causes an excess of the acid to accumulate in the blood and in the joints. Crystals of uric acid collect in joint capsules as tophi, causing acute inflammation. The big toe is commonly affected. Gout is associated with overeating and overdrinking. Treatment involves the use of anti- inflammatory drugs, and abstention from rich foods and excessive alcohol.

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