. Depression. Depressed woman crouching in the corner of a room. She may have feelings of loneliness, sadness or hopelessness. Sufferers of depression tend to have a general loss of interest in life, combined with a sense of reduced emotional well-being. Depression appears to affect more women than men. However, this may just reflect that women seek medical advice more often. Alternatively she may suffer from agoraphobia, or the fear of open or public places. MODEL RELEASED