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Glutamate transporter nanobody therapy, illustration
Glutamate transporter nanobody therapy. Illustration of nanobodies acting as inhibitors of glutamate transport across a cell membrane. The figure shows a nanobody (blue and white) binding to a vesicular glutamate transporter (VGLUT) protein (pink). The area of recognition between the two (the epitope) is highlighted in blue. This nanobody, when binding to the transporter protein, blocks its function which is the re-uptake of the neurotransmitter glutamate in the neuronal synapses. This inhibition has potential use in treating a range of common neurological diseases.
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