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Activin A receptor type I protein, molecular model
Molecular model of the cytoplasmic domain of the activin A receptor type I (ACVR1) protein (beige, pale yellow and red) bound to its natural inhibitor FK506-binding protein 12 (FKB12, orange ribbon) and the synthetic inhibitor RK-71807 (spheres). ACVR1 plays a role in the bone morphogenic protein (BMP) pathway. A mutant form of the protein is responsible for the rare genetic disease fibrodysplasia ossificans progressiva (FOP). FOP is a disease where fibrous tissues, including muscle, tendons and ligaments, are gradually replaced by bone (ossified). The mutation in ACVR1 decreases its affinity for FKB12, leading to increased activity of the protein and therefore increased production of bone., Photo by RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY
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