Nodular lymphocyte-predominant Hodgkin lymphoma, micrograph

Light micrograph of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). NLPHL is a rare, germinal centre-derived, B-cell lymphoma that is biologically distinct from classic Hodgkin lymphoma (cHL). The two entities differ in their clinical presentation, epidemiology, morphology, immunophenotype, and molecular genetics. Nodular and B-cell rich patterns of NLPHL are more common and considered typical. They present with localized disease and generally pursue an indolent course. Less frequently, the involved lymph nodes show more diffuse or T-cell rich infiltrates (variant patterns). These patients frequently have advanced disease with splenic, liver, or bone marrow involvement, B-symptoms, and a more aggressive clinical course., Photo by WEBPATHOLOGY/SCIENCE PHOTO LIBRARY