Clear cell sarcoma of kidney, light micrograph

Clear cell sarcoma of kidney (CCSK), light micrograph. CCSK is a rare malignant mesenchymal neoplasm that is seen predominantly in pediatric patients. Although rare, it is the second most common pediatric renal tumour after Wilms tumour. It is characterized by aggressive behaviour, late recurrences, and a tendency to metastasize to bones (hence the previous name - bone metastasizing renal tumour of childhood). It shows two specific, mutually exclusive genetic alterations. About 85% of cases show internal tandem duplications in BCL-6 coreceptor (BCOR). Another 10% of cases have a translocation t(10;17) creating the fusion gene YWHAE-NUTM2B/E. The remaining 5% carry neither genetic alteration. This image of classic pattern of CCSK shows nests of small uniform polygonal to ovoid to spindle cells, separated by regularly spaced vascular channels., by WEBPATHOLOGY/SCIENCE PHOTO LIBRARY