Illustration of human gamma interferon as a glass surface model with indicated deeper ribbon model on dark background. Gamma interferon is produced by TH1 cells after contact with a macrophage that has incorporated (phagocytosed) bacteria. The main function of interferon-gamma is to activate macrophages and thereby strengthen cellular defenses. These macrophages increase the production of nitric oxide, which is toxic to bacteria, and reactive oxygen radicals. Furthermore, macrophages activated in this way enhance the fusion of phagosomes with lysosomes inside them. The illustration is based on structural data from Samudzi, C.T., Rubin, J.R., by medicalgraphics/F1online
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